Chemoembolization With Doxorubicin-Eluting Beads for Unresectable Hepatocellular Carcinoma: Five-Year Survival Analysis
| Autor: | Aspasia Stefaniotou, Katerina Chatzimichael, Athanasios Marinis, Spyros Rizos, Mary Pomoni, John Koskinas, Katerina Malagari, Hippocrates Moschouris, Efthymia Alexopoulou, Achilles Chatziioannou, Alexios Kelekis, Evanthia Bouma, Spyridon P. Dourakis, Dimitrios A. Kelekis, Nikolaos Kelekis |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Oncology medicine.medical_specialty Carcinoma Hepatocellular Contrast Media Gastroenterology Doxorubicin-Eluting Beads Internal medicine On demand polycyclic compounds medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Doxorubicin Prospective Studies Chemoembolization Therapeutic Ultrasonography Interventional Survival analysis Aged Antibiotics Antineoplastic Neovascularization Pathologic Drug eluting beads business.industry Liver Neoplasms medicine.disease Magnetic Resonance Imaging Survival Analysis digestive system diseases Treatment Outcome Hepatocellular carcinoma Female Ultrasonography Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | CardioVascular and Interventional Radiology. 35:1119-1128 |
| ISSN: | 1432-086X 0174-1551 |
| DOI: | 10.1007/s00270-012-0394-0 |
| Popis: | The purpose of this study was to report on the 5-year survival of hepatocellular carcinoma (HCC) patients treated with DC Bead loaded with doxorubicin (DEB-DOX) in a scheduled scheme in up to three treatments and thereafter on demand.173 HCC patients not suitable for curable treatments were prospectively enrolled (mean age 70.4 ± 7.4 years). Child-Pugh (Child) class was A/B (102/71 [59/41 %]), Okuda stage was 0/1/2 (91/61/19 [53.2/35.7/11.1 %]), and mean lesion diameter was 7.6 ± 2.1 cm. Lesion morphology was one dominant ≤5 cm (22 %), one dominant5 cm (41.6 %), multifocal ≤5 (26 %), and multifocal5 (10.4 %).Overall survival at 1, 2, 3, 4, and 5 years was 93.6, 83.8, 62, 41.04, and 22.5 %, with higher rates achieved in Child class A compared with Child class B patients (95, 88.2, 61.7, 45, and 29.4 % vs. 91.5, 75, 50.7, 35.2, and 12.8 %). Mean overall survival was 43.8 months (range 1.2-64.8). Cumulative survival was better for Child class A compared with Child class B patients (p = 0.029). For patients with dominant lesions ≤5 cm 1-, 2-, 3-, 4-, and 5-year survival rates were 100, 95.2, 71.4, 66.6, and 47.6 % for Child class A and 94.1, 88.2, 58.8, 41.2, 29.4, and 23.5 % for Child class B patients. Regarding DEB-DOX treatment, multivariate analysis identified number of lesions (p = 0.033), lesion vascularity (p0.0001), initially achieved complete response (p0.0001), and objective response (p = 0.046) as significant and independent determinants of 5-year survival.DEB-DOX results, with high rates of 5-year survival for patients, not amenable to curative treatments. Number of lesions, lesion vascularity, and local response were significant independent determinants of 5-year survival. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink