Circulating anti‐citrullinated protein antibodies containing secretory component are prognostic for arthritis onset in at‐risk patients

Autor: Anna Svärd, Jonas Wetterö, Alf Kastbom, Klara Martinsson, K Roos Ljungberg
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
rheumatoid arthritis
Male
Arthritis
Anti-Citrullinated Protein Antibodies
Arthritis
Rheumatoid
0302 clinical medicine
immune system diseases
secretory component
Immunology and Allergy
Longitudinal Studies
Prospective Studies
skin and connective tissue diseases
mucosa
biology
Hazard ratio
Anti–citrullinated protein antibody
Middle Aged
Prognosis
Isotype
Immunoglobulin Isotypes
at-risk patients
Rheumatoid arthritis
Original Article
Female
Antibody
musculoskeletal diseases
Immunology
Gastroenterology and Hepatology
03 medical and health sciences
Rheumatoid Factor
medicine
Gastroenterologi
at‐risk patients
Humans
anti-citrullinated protein antibodies
Rheumatology and Autoimmunity
Autoantibodies
Reumatologi och inflammation
business.industry
Proportional hazards model
Autoantibody
anti‐citrullinated protein antibodies
Original Articles
medicine.disease
Autoimmunity/Autoimmune diseases
Secretory Component
030104 developmental biology
biology.protein
business
030215 immunology
Zdroj: Clinical and Experimental Immunology
ISSN: 1365-2249
0009-9104
Popis: Summary Autoantibodies related to rheumatoid arthritis (RA), such as anti‐citrullinated protein antibodies (ACPA), are often detectable in the preclinical period years before arthritis onset. However, events triggering arthritis development remain incompletely known. We aimed to determine whether ACPA isotype levels are prognostic for arthritis development in patients presenting with immunoglobulin (Ig)G ACPA and musculoskeletal pain. Study participants (n = 82) had musculoskeletal pain of any sort and duration and a positive IgG ACPA test. None of the patients had arthritis upon clinical examination at baseline, but during follow‐up (mean = 6 years), 48% developed at least one arthritic joint. IgG, IgA, IgM and secretory component (SC)‐containing ACPA was measured in longitudinally collected serum samples. Cox regression analysis was performed to test the prognostic value of baseline antibody levels and changes over time. All analysed ACPA isotype levels were associated with arthritis development in univariable Cox regression analysis. In multivariable analysis, baseline SC ACPA levels were independently prognostic for arthritis development in multivariable analysis [hazard ratio (HR) = 1·006, 95% confidence interval (CI) = 1·001–1·010, P = 0·012]. There were no significant changes in ACPA isotype levels over time, and no significant association between changes over time and arthritis development. In this prospective longitudinal study, baseline serum SC ACPA levels, but neither IgG, IgA nor IgM ACPA are prognostic for future arthritis development. Repeated measurement of ACPA isotypes do not bring additional prognostic value. The results reinforce a mucosal connection in RA development and encourage further exploration of the mechanisms underlying secretory ACPA formation as a trigger for arthritis development.
Smoking habits in relation to different anti‐citrullinated protein antibody (ACPA) isotypes (IgG, IgA, IgM and SC) in TIRx patients. *p‐value
Databáze: OpenAIRE
Externí odkaz: