Effects of Bariatric Surgery in Obese Patients With Hypertension
| Autor: | Camila Ragne Torreglosa, Carlos A. Schiavon, Lucas P. Damiani, Carlos Henrique G. Uchôa, Frederico L.J. Monteiro, Helio Halpern, Marcio G. de Souza, Luiz Aparecido Bortolotto, Celso Amodeo, Angela Cristine Bersch-Ferreira, Eliana Vieira Santucci, Dimas Ikeoka, Julia Caldas Frayha, Juliana D Oliveira, Ricardo Cohen, Alexandre Biasi Cavalcanti, Patricia Malvina Noujaim, Priscila Regina Torres Bueno, Otavio Berwanger, Renato Hideo Nakagawa Santos, Luciano F. Drager |
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| Rok vydání: | 2018 |
| Předmět: |
HIPERTENSÃO
medicine.medical_specialty business.industry Gastric bypass 030204 cardiovascular system & hematology medicine.disease Obesity law.invention Surgery 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Physiology (medical) Diabetes mellitus medicine In patient 030212 general & internal medicine Cardiology and Cardiovascular Medicine business |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | Background: Recent research efforts on bariatric surgery have focused on metabolic and diabetes mellitus resolution. Randomized trials designed to assess the impact of bariatric surgery in patients with obesity and hypertension are needed. Methods: In this randomized, single-center, nonblinded trial, we included patients with hypertension (using ≥2 medications at maximum doses or >2 at moderate doses) and a body mass index between 30.0 and 39.9 kg/m 2 . Patients were randomized to Roux-en-Y gastric bypass plus medical therapy or medical therapy alone. The primary end point was reduction of ≥30% of the total number of antihypertensive medications while maintaining systolic and diastolic blood pressure Results: We included 100 patients (76% female, mean age 43.8±9.2 years, mean body mass index 36.9±2.7 kg/m2), and 96% completed follow-up. Reduction of ≥30% of the total number of antihypertensive medications while maintaining controlled blood pressure occurred in 41 of 49 patients from the gastric bypass group (83.7%) compared with 6 of 47 patients (12.8%) from the control group with a rate ratio of 6.6 (95% confidence interval, 3.1–14.0; P P =0.005). Eleven patients (22.4%) from the gastric bypass group and none in the control group were able to achieve SPRINT levels without antihypertensives. Waist circumference, body mass index, fasting plasma glucose, glycohemoglobin, low-density lipoprotein cholesterol, triglycerides, high-sensitivity C-reactive protein, and 10-year Framingham risk score were lower in the gastric bypass than in the control group. Conclusions: Bariatric surgery represents an effective strategy for blood pressure control in a broad population of patients with obesity and hypertension. Clinical Trial Registration: URL: https://clinicaltrials.gov . Unique identifier: NCT01784848. |
| Databáze: | OpenAIRE |
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