Characterization of pABVA01, a Plasmid Encoding the OXA-24 Carbapenemase from Italian Isolates of Acinetobacter baumannii▿
| Autor: | Paolo Visca, Francesco Luzzaro, Tommaso Giani, Gian Maria Rossolini, Silvia D'Arezzo, Nicola Petrosillo, Alessandro Capone, Marco Maria D'Andrea |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Acinetobacter baumannii
Genotype Inverted repeat Sequence analysis Molecular Sequence Data Microbial Sensitivity Tests Biology Settore BIO/19 - Microbiologia Generale beta-Lactamases Microbiology chemistry.chemical_compound Open Reading Frames Plasmid Bacterial Proteins Mechanisms of Resistance polycyclic compounds Pharmacology (medical) Pharmacology Genetics Sequence Analysis DNA Acinetobacter biochemical phenomena metabolism and nutrition Settore MED/07 - Microbiologia e Microbiologia Clinica biology.organism_classification Anti-Bacterial Agents Infectious Diseases chemistry Homologous recombination DNA Plasmids |
| Popis: | Two epidemiologically unrelated carbapenem-resistant Acinetobacter baumannii isolates were investigated as representatives of the first Italian isolates producing the OXA-24 carbapenemase. Both isolates were of European clonal lineage II and carried an identical OXA-24-encoding plasmid, named pABVA01. Comparative analysis revealed that in pABVA01, bla OXA-24 was part of a DNA module flanked by conserved inverted repeats homologous to XerC/XerD binding sites, which in other Acinetobacter plasmids flank different DNA modules, suggesting mobilization by a novel site-specific recombination mechanism. |
| Databáze: | OpenAIRE |
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