The selective 5-HT2 receptor antagonist amperozide attenuates 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane-induced inhibition of male rat sexual behavior
| Autor: | T Klint, I L Dahlgren, K Larsson |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Agonist medicine.medical_specialty Ketanserin medicine.drug_class Ritanserin Pharmacology Piperazines Amperozide Sexual Behavior Animal chemistry.chemical_compound Internal medicine medicine Animals Ergolines Alprenolol 5-HT receptor Mesulergine musculoskeletal neural and ocular physiology 5-HT2 receptor Amphetamines Rats Inbred Strains Receptor antagonist Rats Endocrinology chemistry cardiovascular system Serotonin Antagonists medicine.drug |
| Zdroj: | European Journal of Pharmacology. 212:241-246 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(92)90336-3 |
| Popis: | This study was aimed at exploring the role of 5-HT2/5-HT1C neurotransmission in male rat sexual behavior. The administration of the 5-HT2/5-HT1C agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) (1 mg/kg), suppressed sexual activity in most of the animals. The suppressive effect of DOI was antagonized by treatment with amperozide, a selective 5-HT2 receptor antagonist, in doses which did not by themselves affect sexual activity. In addition, several other serotonin antagonists were tested with varying affinity profiles for 5-HT2/5-HT1C receptors, including ketanserin, ritanserin, and mesulergine. All these compounds antagonized the suppressive action of DOI. In contrast, no antagonizing effect was obtained by treatment with (-)-alprenolol, a 5-HT1A antagonist. The present findings suggest that 5-HT2/5-HT1C receptors might be involved in the neural control of male rat sexual behavior, presumably by exerting an inhibitory influence on the behavior. |
| Databáze: | OpenAIRE |
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