N-acetyltransferase (NAT2) polymorphism and breast cancer susceptibility: a lack of association in a case-control study of Turkish population

Autor: Ann K. Daly, S. Cholerton, Neslihan Aygun Kocabas, Ali Esat Karakaya, Semra Sardas
Rok vydání: 2004
Předmět:
Oncology
Adult
Risk
medicine.medical_specialty
Turkish population
Genotype
Turkey
Arylamine N-Acetyltransferase
Breast Neoplasms
010501 environmental sciences
Toxicology
030226 pharmacology & pharmacy
01 natural sciences
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Breast cancer
Gene Frequency
Internal medicine
medicine
Odds Ratio
Humans
Allele frequency
Carcinogen
0105 earth and related environmental sciences
Aged
chemistry.chemical_classification
Genetics
Menarche
Polymorphism
Genetic
business.industry
Reverse Transcriptase Polymerase Chain Reaction
Smoking
Case-control study
Age Factors
Acetylation
Odds ratio
Middle Aged
medicine.disease
Postmenopause
Kinetics
chemistry
Heterocyclic amine
Case-Control Studies
Female
business
Polymorphism
Restriction Fragment Length
Zdroj: International journal of toxicology. 23(1)
ISSN: 1091-5818
Popis: Increased exposure to environmental carcinogens, including several aromatic and heterocyclic amines (HAs), is suspected to be one factor contributing to incidence of breast cancer. The N-acetyltransferase 2 ( NAT2) acetylation polymorphism have been associated with a number of drug-induced toxicities and cancer in various tissues, resulting from decreased capacity to activate/deactivate several aromatic amine, hydrazine drugs, as well as HA carcinogens. Ethnic differences exist in NAT2 genotype frequencies, which may be a factor in cancer incidence. Our present case-control study in Turkey was performed to explore the association between NAT2 genetic polymorphism and individual susceptibility to breast cancer. The NAT2 genotypes (* 4, * 12A, *5 A, * 5B, * 5C, * 6, * 7) were determined using the polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) assay in 84 breast cancer patients and 103 healthy controls, and 50% and 56.3%, respectively, were found to be slow acetylator genotypes. There was no significant difference in risk for breast cancer development among patients with rapid and slow acetylators, with adjusted odds ratio 0.78 (95% confidence interval 0.44 to 1.38). Also, risk was not affected by different variables. To our knowledge, this is the first genetic study on the association of NAT2 genotypes with breast cancer in the Turkish population, and this finding showed that NAT2 polymorphism does not play an important role in breast cancer risk of Turkish women by altering the capacity in deactivation of environmental carcinogens, even though small sample size and wide confidence interval.
Databáze: OpenAIRE
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