Inflammatory Mediators and Pain in the First Year After Acute Episode of Low-Back Pain in Elderly Women
| Autor: | Diogo Carvalho Felício, Nayza Maciel de Britto Rosa, Daniele Sirineu Pereira, Bárbara Zille Queiroz, Leani Souza Máximo Pereira, Renata Muniz Freire Vinhal Siqueira Jardim, Amanda Aparecida Oliveira Leopoldino, André Gustavo Pereira de Andrade, Renata Antunes Lopes, Juscélio P. Silva |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Time Factors Longitudinal data Enzyme-Linked Immunosorbent Assay Physical Therapy Sports Therapy and Rehabilitation Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Tnf receptor 1 health services administration Internal medicine medicine Humans Longitudinal Studies 030212 general & internal medicine Interleukin 6 Tumor necrosis factor α Aged Pain Measurement Aged 80 and over biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Rehabilitation Plasma levels Low back pain Receptors Tumor Necrosis Factor Type I Acute Disease biology.protein Physical therapy population characteristics Female Tumor necrosis factor alpha Inflammation Mediators medicine.symptom business Low Back Pain Brazil 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | American Journal of Physical Medicine & Rehabilitation. 96:535-540 |
| ISSN: | 0894-9115 |
| DOI: | 10.1097/phm.0000000000000661 |
| Popis: | The aims of this study were to determine the course of plasma levels of inflammatory mediators (interleukin 6 [IL-6], tumor necrosis factor α [TNF-α], soluble TNF receptor 1 [sTNF-R1]) and the severity of low-back pain (LBP) over 6 to 12 months after an acute episode of LBP in elderly women and to establish an association between inflammatory mediators and LBP recovery.This was a longitudinal study of a subsample (155 elderly women with acute LBP, aged ≥65 years) of the international Back Complaints in the Elders cohort study. Plasma levels of IL-6, TNF-α, and sTNF-R1 were measured using enzyme-linked immunosorbent assays and pain severity using the numerical pain scale.There was a decrease in the severity of LBP (P = 0.033) and in the levels of IL-6 and TNF-α (P0.001) and an increase in sTNF-R1 (P0.001) in the first year after an acute episode of LBP. The probability of occurrence of pain relief at the 12-month follow-up was 2.22 times higher in elderly women who had low levels of IL-6 (1.58 pg/mL) at baseline.Our findings showed a relationship between inflammation and LBP by establishing that low IL-6 plasma levels preceded outcome (LBP recovery), supporting the concept that proinflammatory cytokines promote pain. |
| Databáze: | OpenAIRE |
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