Dramatic effect of vitamin D supplementation and a gluten-free diet on bone mineral density in a patient with celiac disease
| Autor: | Donald R. Duerksen, William D. Leslie, Massud Ali |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Malabsorption Endocrinology Diabetes and Metabolism Osteoporosis Gastroenterology vitamin D deficiency Diet Gluten-Free Absorptiometry Photon Bone Density Internal medicine medicine Vitamin D and neurology Humans Radiology Nuclear Medicine and imaging Orthopedics and Sports Medicine Vitamin D Bone mineral Osteomalacia Lumbar Vertebrae business.industry medicine.disease Malnutrition Celiac Disease Gluten free Female Hip Joint business |
| Zdroj: | Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry. 15(1) |
| ISSN: | 1094-6950 |
| Popis: | Low bone mineral density (BMD) and osteoporosis are frequent findings in patients with celiac disease (CD), affecting up to 70% of individuals (1,2). The pathogenesis is unknown, but 2 potential mechanisms include malabsorption of calcium, vitamin D, and other nutrients, which lead to malnutrition, and release of proinflammatory mediators (3). The effects of a gluten-free diet (GFD) have been evaluated in CD patients, and many have shown modest improvements in BMD (a mean increase of w5% in the first year in longitudinally followed patients) (4). Vitamin D deficiency and osteomalacia may also be associated with CD and have been reported as the presenting manifestation of CD (5). In this report, we describe a case of CD with dramatic BMD improvement with a GFD, calcium, and vitamin D supplementation. We review the factors affecting BMD in CD and the importance of recognizing vitamin D deficiency in CD. |
| Databáze: | OpenAIRE |
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