Larval Taenia crassiceps secretes a protein with characteristics of murine interferon-γ
| Autor: | Raymond E. Kuhn, Thomas Pg, R. J. Spolski, E. J. See, K. A. Mooney |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Cellular immunity
T-Lymphocytes medicine.medical_treatment Lymphocyte Activation Nitric Oxide Cell Line Nitric oxide Epitopes Interferon-gamma Mice chemistry.chemical_compound Immune system Interferon medicine Animals Interferon gamma Peritoneal Cavity Taenia crassiceps Mice Inbred BALB C Taenia General Veterinary biology Cysticercosis Immune Sera Macrophages Helminth Proteins General Medicine biology.organism_classification Molecular biology Interleukin-10 Infectious Diseases Cytokine Secretory protein chemistry Larva Insect Science Immunology Female Parasitology Spleen medicine.drug |
| Zdroj: | Parasitology Research. 88:431-438 |
| ISSN: | 1432-1955 0932-0113 |
| DOI: | 10.1007/s00436-002-0590-y |
| Popis: | Previous studies have shown that excretory/secretory products of larval Taenia crassiceps have immunomodulatory activities. We report here that one of these products, termed p66, possesses activities that mimic some characteristics of murine interferon-gamma (IFN-gamma). Purified p66 cross-reacts with anti-murine IFN-gamma on immunoblots and increases concanavalin-A-induced splenic T-cell proliferative responses of normal and chronically infected mice. It has also been shown that p66 induces enhanced IFN-gamma and interleukin-10 (IL-10) production in cells from infected or normal mice. Adherent and non-adherent peritoneal exudates cells were stimulated with p66 and showed that the adherent cells were induced to produce IL-10 and that the non-adherent cells were induced to produce IFN-gamma. p66 was shown as well to upregulate nitric oxide production in macrophages and two T-cell lines, IEL and YAC-1, were shown to be stimulated to produce IFN-gamma and IL-10, respectively, by p66. Although the significance of p66 in immunoregulation is not known, we show here that this molecule mimics characteristics of IFN-gamma. |
| Databáze: | OpenAIRE |
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