Necrotizing Enterocolitis and the Microbiome: Current Status and Future Directions
| Autor: | Gautam Dantas, Robert Thänert, Phillip I. Tarr, Barbara B. Warner, Eric C. Keen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Supplement Articles Microbial dysbiosis 03 medical and health sciences 0302 clinical medicine Enterocolitis Necrotizing Risk Factors 030225 pediatrics medicine Humans Immunology and Allergy Barrier integrity Vulnerable population Microbiome Intensive care medicine business.industry Infant Newborn medicine.disease digestive system diseases Gastrointestinal Microbiome 030104 developmental biology Infectious Diseases Gastrointestinal disorder Host-Pathogen Interactions Necrotizing enterocolitis Dysbiosis business Infant Premature |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Decades of research have failed to define the pathophysiology of necrotizing enterocolitis (NEC), a devastating pediatric gastrointestinal disorder of preterm infants. However, evidence suggests that host-microbiota interactions, in which microbial dysbiosis is followed by loss of barrier integrity, inflammation, and necrosis, are central to NEC development. Thus, greater knowledge of the preterm infant microbiome could accelerate attempts to diagnose, treat, and prevent NEC. In this article, we summarize clinical characteristics of and risk factors for NEC, the structure of the pre-event NEC microbiome, how this community interfaces with host immunology, and microbiome-based approaches that might prevent or lessen the severity of NEC in this very vulnerable population. |
| Databáze: | OpenAIRE |
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