Longitudinal adrenal gland measurements and growth trajectories as risk markers for late preterm delivery
Autor: | Kurt Hecher, Petra C. Arck, Mirja Pagenkemper, Franziska Rüber, J. Goletzke, Christian Wiessner, Anke Diemert |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
medicine.medical_specialty Reproductive medicine Gestational Age Risk Assessment lcsh:Gynecology and obstetrics Ultrasonography Prenatal Fetal Development 03 medical and health sciences Fetus 0302 clinical medicine Pregnancy Adrenal Glands medicine Late preterm Humans 030212 general & internal medicine lcsh:RG1-991 Adrenal gland 030219 obstetrics & reproductive medicine Fetal adrenal business.industry Obstetrics Preterm labour Obstetrics and Gynecology Fetal zone Preterm birth medicine.disease Fetal ultrasound medicine.anatomical_structure HPA-axis Cohort embryonic structures Fetal adrenal gland Premature Birth Female Analysis of variance business Research Article |
Zdroj: | BMC Pregnancy and Childbirth, Vol 20, Iss 1, Pp 1-9 (2020) BMC Pregnancy and Childbirth |
ISSN: | 1471-2393 |
Popis: | Background The fetal adrenal gland receives rising awareness as a predictor of spontaneous preterm birth. We hereby provide longitudinal growth assessments of the fetal adrenal gland in a low risk population with an additional focus on trajectories in fetuses born preterm. Methods Fetal adrenal gland was assessed via transabdominal ultrasound at gestational weeks (gw) 24–26, 28–30, and 34–36 in a low-risk pregnancy cohort. Longitudinal trajectories of the total gland and the mark (so called fetal zone) as well as ratio of fetal zone width/ total widths (w/W) were analyzed using repeated ANOVA analyses. To compare trajectories of the ratio w/W for preterm and term fetuses respectively, as well as women with and without clinical signs of preterm labor, the propensity score method was applied. Results Fetal zone width increased over the course of pregnancy (p p n = 327). Comparing the trajectories of the ratio w/W in fetuses born preterm (n = 11) with propensity-score matched term born fetuses (n = 22), a decrease between gw 24–26 and 28–30 was observed in both groups, which continued to decrease for the term born fetuses. However, in preterm born fetuses, the ratio increased above the term born values at gw 34–36. Conclusion Our study provides for the first time longitudinal growth data on the fetal adrenal gland and supports the hypothesis that fetal zone enlargement is associated with preterm birth which could play an important role in risk-prediction. |
Databáze: | OpenAIRE |
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