Vitamin D status and prevalent early age-related macular degeneration in African Americans and Caucasians: The Atherosclerosis Risk in Communities (ARIC) Study
| Autor: | Jing Nie, Kristin J. Meyers, Chris Andrews, Pamela L. Lutsey, Amy E. Millen, Michael J. LaMonte, Barbara E.K. Klein, Ronald Klein, Julie A. Mares, Michelle W. Sahli |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Nutritional Status Medicine (miscellaneous) 030204 cardiovascular system & hematology Article White People Macular Degeneration 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Epidemiology Prevalence Vitamin D and neurology Humans Medicine Prospective Studies Vitamin D Nutrition and Dietetics business.industry Odds ratio Middle Aged Macular degeneration Atherosclerosis medicine.disease eye diseases Confidence interval Surgery Black or African American Cross-Sectional Studies Logistic Models Blood pressure Cohort 030221 ophthalmology & optometry Female sense organs Geriatrics and Gerontology business Biomarkers Cohort study |
| Zdroj: | The journal of nutrition, health & aging. 21:772-780 |
| ISSN: | 1760-4788 1279-7707 1990-1992 |
| Popis: | Vitamin D status has been hypothesized to protect against development of early age-related macular degeneration (AMD) via its anti-inflammatory properties and its possible beneficial influence on blood pressure control. We investigated the association between vitamin D status and prevalent early AMD in a community-based cohort. This was a cross-sectional study. This was a secondary data analysis of already existing data from the Atherosclerosis Risk in Communities Study (ARIC) cohort collected from 1990 to 1995. There were 9,734 (7,779 Caucasians, 1,955 African American) ARIC participants (aged 46 to 70 at visit 2 [1990-1992]) with 25(OH)D data available at visit 2, AMD assessment at visit 3 (1993-1995), and complete covariate data. Vitamin D status was assessed with serum 25-hydroxyvitamin D (25(OH)D) concentrations from bloods drawn at visit 2. Prevalent, early AMD (n=511) was assessed at visit 3 (1993-95) with nonmydriatic retinal photographs of one randomly chosen eye. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for early AMD by categories of 25(OH)D in nmol/L (deficient |
| Databáze: | OpenAIRE |
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