Effect of Centella asiatica L (Umbelliferae) on Normal and Dexamethasone-Suppressed Wound Healing in Wistar Albino Rats
| Autor: | B. Somashekar Shetty, A. L. Udupa, Saraswati L. Udupa, S. N. Somayaji |
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| Rok vydání: | 2006 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Contraction (grammar) Incision wound Administration Topical Pharmacology Dexamethasone Centella 03 medical and health sciences Hydroxyproline chemistry.chemical_compound 0302 clinical medicine Animals Medicine Rats Wistar Glucocorticoids Wound Healing integumentary system biology Plant Extracts business.industry Granulation tissue Histology General Medicine biology.organism_classification Rats Surgery Disease Models Animal Treatment Outcome 030104 developmental biology medicine.anatomical_structure chemistry Wounds and Injuries Female business Wound healing 030217 neurology & neurosurgery Phytotherapy medicine.drug |
| Zdroj: | The International Journal of Lower Extremity Wounds. 5:137-143 |
| ISSN: | 1552-6941 1534-7346 |
| DOI: | 10.1177/1534734606291313 |
| Popis: | Centella asiatica is a reputed medicinal plant used in the treatment of various skin diseases in the Indian system of medicine. The objective of the study presented in this article was to evaluate the wound-healing potential of the ethanolic extract of the plant in both normal and dexamethasone-suppressed wound healing. The study was done on Wistar albino rats using incision, excision, and dead space wounds models. The extract of C asiatica significantly increased the wound breaking strength in incision wound model compared to controls (P < .001). The extract-treated wounds were found to epithelize faster, and the rate of wound contraction was significantly increased as compared to control wounds (P < .001). Wet and dry granulation tissue weights, granulation tissue breaking strength, and hydroxyproline content in a dead space wound model also increased at statistically significant levels as shown. The extract of the leaves had the effect of attenuating the known effects of dexamethasone healing in all wound models (P < .001, P < .05). The results indicated that the leaf extract promotes wound healing significantly and is able to overcome the wound-healing suppressing action of dexamethasone in a rat model. These observations were supported by histology findings. |
| Databáze: | OpenAIRE |
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