Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

Autor:	Timothy W. Behrens, Pui-Yan Kwok, Nataliya Shifrin, Michael F. Seldin, Susan Manzi, Peter K. Gregersen, Michelle Petri, M. Ilyas Kamboh, Kimberly E. Taylor, Joanne Nititham, Lindsey A. Criswell, Ward Ortmann, Stacy L. Musone, Ricardo C. Ferreira, Timothy T. Lu, Averil Ma
Rok vydání:	2009
Předmět:	Systemic disease Single-nucleotide polymorphism Biology Bioinformatics TNFAIP3 Polymorphism Single Nucleotide White People Article Ubiquitin immune system diseases hemic and lymphatic diseases Genetics medicine Humans Lupus Erythematosus Systemic Genetic Predisposition to Disease skin and connective tissue diseases Tumor Necrosis Factor alpha-Induced Protein 3 Lupus erythematosus Intracellular Signaling Peptides and Proteins Nuclear Proteins medicine.disease Connective tissue disease DNA-Binding Proteins biology.protein Tumor necrosis factor alpha
Zdroj:	Nature genetics. 40(9)
ISSN:	1061-4036 1319-2841
Popis:	The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-kappaB-dependent signaling and prevents inflammation. We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are associated with systemic lupus erythematosus (SLE) among individuals of European ancestry. These findings provide critical links between A20 and the etiology of SLE.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7f97a546bdf003b048259ad39ab355 https://pubmed.ncbi.nlm.nih.gov/19165919 Zobrazit plný text záznamu