Novel sex-specific influence of parental factors on small-for-gestational-age newborns
| Autor: | Xiaolei Wang, Shi Wu Wen, Hong Zhuan Tan, Hao Ren Wang, Meng Yuan Tian, Shu Juan Ma, Ravi Retnakaran, Hui Jun Lin, Meng Shi Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Parents medicine.medical_specialty Future studies Epidemiology Birth weight lcsh:Medicine Gestational Age Logistic regression Article Body Mass Index Fetal Development 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Birth Weight Humans 030212 general & internal medicine Fetal programming lcsh:Science 2. Zero hunger 030219 obstetrics & reproductive medicine Multidisciplinary Obstetrics business.industry lcsh:R Infant Newborn Paediatrics medicine.disease Sex specific Body Height Risk factors Infant Small for Gestational Age Cohort Small for gestational age Female lcsh:Q business Body mass index |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-76196-x |
| Popis: | Since fetal programming is sex-specific, there may also be sex-specific in parental influences on newborn birth weight. We aimed to investigate the influence of parental factors on small-for-gestational-age (SGA) infants of different sexes. Based on a pre-pregnancy cohort, multivariate logistic regression was used. 2275 couples were included for analysis. Significant associations were observed among paternal height, pre-pregnancy body mass index (BMI), and SGA in male infants; among maternal height, pre-pregnancy BMI, and SGA in female infants, and among other maternal factors and SGA in both male and female infants. Such sex specificity may be related to genetic, epigenetic, or hormonal influences between parents and infants. In conclusion, there is a sex specificity in the effect of parental height and pre-pregnancy BMI on SGA. The data suggest that future studies on infants should consider the sex-specific differences between the effects of genetic or environmental factors and infants. |
| Databáze: | OpenAIRE |
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