| Autor: |
Marin-Pierre Gémin, Rachelle Lanceleur, Lisa Meslier, Fabienne Hervé, Damien Réveillon, Zouher Amzil, Eva Ternon, Olivier P. Thomas, Valérie Fessard |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Environmental Toxicology And Pharmacology (1382-6689) (Elsevier BV), 2022-08, Vol. 94, P. 103909 (11p.) |
| ISSN: |
1382-6689 |
| DOI: |
10.1016/j.etap.2022.103909 |
| Popis: |
Human intoxications in the Mediterranean Sea have been linked to blooms of the dinoflagellate Ostreopsis cf. ovata, producer of palytoxin (PlTX)-like toxins called ovatoxins (OVTXs). Exposure routes include only inhalation and contact, although PlTX-poisoning by seafood has been described in tropical regions. To address the impact of OVTXs on the intestinal barrier, dinoflagellate extracts, purified OVTX-a and -d and PlTX were tested on differentiated Caco-2 cells. Viability, inflammatory response and barrier integrity were recorded after 24 h treatment. OVTX-a and -d were not cytotoxic up to 20 ng/mL but increased IL-8 release, although to a lesser extent compared to PlTX. While PlTX and OVTX-a (at 0.5 and 5 ng/mL respectively) affected intestinal barrier integrity, OVTX-d up to 5 ng/mL did not. Overall, OVTX-d was shown to be less toxic than OVTX-a and PlTX. Therefore, oral exposure to OVTX-a and -d could provoked lower acute toxicity than PlTX. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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