Phenolic Lipids Affect the Activity and Conformation of Acetylcholinesterase from Electrophorus electricus (Electric eel)
| Autor: | Arkadiusz Kozubek, Alicja Janiszewska, Maria Stasiuk |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Fish Proteins
Chemical structure Trp fluorescence lcsh:TX341-641 phenolic lipids Article chemistry.chemical_compound Phenols Animals resorcinolic lipids acetylcholinesterase Cholinesterase chemistry.chemical_classification Nutrition and Dietetics biology Anacardium food and beverages biology.organism_classification Lipids Acetylcholinesterase Electric eel Enzyme chemistry Biochemistry Electrophorus biology.protein Cholinesterase Inhibitors lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients; Volume 6; Issue 5; Pages: 1823-1831 Nutrients, Vol 6, Iss 5, Pp 1823-1831 (2014) Nutrients |
| ISSN: | 2072-6643 |
| Popis: | Phenolic lipids were isolated from rye grains, cashew nutshell liquid (CNSL) from Anacardium occidentale, and fruit bodies of Merrulius tremellosus, and their effects on the electric eel acetylcholinesterase activity and conformation were studied. The observed effect distinctly depended on the chemical structure of the phenolic lipids that were available for interaction with the enzyme. All of the tested compounds reduced the activity of acetylcholinesterase. The degree of inhibition varied, showing a correlation with changes in the conformation of the enzyme tested by the intrinsic fluorescence of the Trp residues of the protein. |
| Databáze: | OpenAIRE |
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