New Mechanisms of Hormone Secretion: MDR-Like Gene Products as Extrusion Pumps for Hormones?
| Autor: | H. Allmeier, V. Höllt, Karl-Friedrich Becker |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Molecular Sequence Data Clinical Biochemistry Drug Resistance ATP-binding cassette transporter Biology Peptide hormone Biochemistry Gene product Endocrinology Internal medicine medicine Animals Humans Gene family Hormone metabolism ATP Binding Cassette Transporter Subfamily B Member 1 Amino Acid Sequence Membrane Glycoproteins Biochemistry (medical) Transporter General Medicine Hormones Steroid hormone ATP-Binding Cassette Transporters Hormone |
| Zdroj: | Hormone and Metabolic Research. 24:210-213 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-2007-1003295 |
| Popis: | P-glycoprotein, the product of the multidrug resistance (MDR1) gene, is an ATP-driven transmembrane pump that increases the resistance of cells by actively exporting toxic chemicals. In addition to transporting anticancer drugs, P-glycoprotein has been reported to extrude a variety of lipophilic drugs, such as calcium channel blockers, phenothiazines, cyclosporines etc. Interestingly, recent experiments suggest that steroid hormones may be physiologic substrates for P-glycoprotein. In addition, there exists a family of transporter genes with high structural homology to P-glycoprotein, the so-called ABC (ATP-binding casette) family. Although the physiological ligands for most of these transporters are unknown, there is increasing evidence that peptides may be transported by some of these proteins. Thus, the a-factor, a farnesylated pheromone with 13 amino acids, is exported from yeast cells by the product of the STE6 gene, a transporter protein with high homology to P-glycoprotein. Recently, we have cloned a novel member of the ABC-transporter gene family from neuroblastoma x glioma hybrid (NG-108-15) cells. This putative transporter gene ("NG-TRA") is expressed in the adrenal gland, kidney and in the brain. High amounts of NG-TRA mRNA are found in a variety of human brain tumors. Whether NG-TRA and/or other MDR-related transporters are involved in the transport of steroids, peptide hormones or growth factors remains to be established. If so, the cellular export of hormones by active pumps may represent a new mechanism of hormone secretion. |
| Databáze: | OpenAIRE |
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