Plasma Levels of Arginine Vasopressin Elevated in Patients with Major Depression
| Autor: | G. M. J. van Kempen, Jaap G. Goekoop, Ank C. Frankhuijzen-Sierevogel, Victor M. Wiegant, E. A. van der Velde, D. de Wied, L. Van Londen |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Vasopressin Hydrocortisone Arginine Neuropeptide Peptide hormone Oxytocin Adrenocorticotropic Hormone Internal medicine medicine Humans Major depressive episode Aged Psychiatric Status Rating Scales Pharmacology Depressive Disorder Psychomotor retardation urogenital system Osmolar Concentration Sodium Middle Aged Pathophysiology Arginine Vasopressin Psychiatry and Mental health Endocrinology nervous system Female medicine.symptom Psychology hormones hormone substitutes and hormone antagonists Personality medicine.drug |
| Zdroj: | Neuropsychopharmacology. 17:284-292 |
| ISSN: | 0893-133X |
| DOI: | 10.1016/s0893-133x(97)00054-7 |
| Popis: | Mentally healthy subjects show increased plasma concentrations of the neuropeptides, arginine vasopressin (AVP) and oxytocin (OT), under conditions of stress, but data are lacking about plasma concentrations of AVP and OT in patients with major depression. We thus assessed plasma concentrations of AVP and OT in patients with major depression (n = 52) and healthy controls (n = 37). Mean plasma AVP concentrations were higher in the group of depressed patients than in controls. A subgroup of 16 patients showed very high levels of plasma AVP, but no other feature differentiating this subgroup from the other patients was found. In-patients showed higher plasma AVP levels than out-patients, and melancholic patients had higher plasma AVP levels than did nonmelancholic patients. Plasma AVP levels were slightly related to psychomotor retardation and significantly inversely to neuroticism. Patients' plasma OT concentrations had a wider range than in controls. AVP and AVP-mediated functions may be a factor in the clinical picture of depression, possibly by influencing the activity of the hypothalamic-pituitary-adrenal axis. |
| Databáze: | OpenAIRE |
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