Assessing the association of rs7574865 STAT4 gene variant and type 1 diabetes mellitus among Egyptian patients
| Autor: | Moushira Erfan Zaki, Mohamed A. El-Dessouky, Somaia Ismail, Samar Samir Abdelmajed, Naglaa Abu-Mandil Hassan, Doaa S. SalahElDin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Autoimmune disease
Type 1 diabetes Signal transducer and activator of transcription 4 business.industry Research Incidence (epidemiology) Insulin medicine.medical_treatment Diabetes type 1 QH426-470 medicine.disease rs7574865 polymorphism Diabetes mellitus Immunology Genotype Genetics medicine Allele business STAT4 TP248.13-248.65 Real-time PCR Biotechnology |
| Zdroj: | Journal of Genetic Engineering and Biotechnology, Vol 19, Iss 1, Pp 1-5 (2021) Journal of Genetic Engineering & Biotechnology |
| ISSN: | 2090-5920 |
| DOI: | 10.1186/s43141-021-00214-2 |
| Popis: | BackgroundVariants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident of multiple autoimmune diseases including type 1 diabetes mellitus (T1D). It is a genetically related auto-immune disorder that resulted from T cell-mediated destruction of pancreatic cells that are in control for the production of insulin in the blood. The current study aimed to clarify the role of STAT4 (rs7574865) variant allelic and genotypic variations in the susceptibility to type 1 diabetes among Egyptians by using the real-time PCR.ResultsA total of 100 patients and 100 controls were genotyped for rs7574865, and the biochemical and anthropometric parameters were measured to show that type 1 diabetic patients had significantly higher levels of HbA1c and triglycerides compared to non-diabetic individuals (PConclusionIt was confirmed by this study that the rs7574865 T allele and GT genotype have a significant correlation with diabetes type 1 incidence among Egyptian patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink