Obstructive sleep apnea pretreatment and posttreatment in symptomatic children with congenital craniofacial malformations
| Autor: | Steven J. Kasten, Mary Berger, Sean P. Edwards, Steven R. Buchman, Louise M. O'Brien, Marta Moraleda-Cibrián |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Pediatrics medicine.medical_specialty genetic structures Adolescent Craniofacial abnormality medicine.medical_treatment Polysomnography Comorbidity urologic and male genital diseases Severity of Illness Index Adenoidectomy Craniofacial Abnormalities Positive-Pressure Respiration Surveys and Questionnaires Severity of illness Positive airway pressure medicine Humans Craniofacial Child Tonsillectomy Sleep Apnea Obstructive medicine.diagnostic_test business.industry medicine.disease Scientific Investigations respiratory tract diseases Obstructive sleep apnea Neurology Anesthesia Child Preschool Female Neurology (clinical) business |
| Zdroj: | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. 11(1) |
| ISSN: | 1550-9397 |
| Popis: | Obstructive sleep symptoms are common in children with craniofacial malformations (CFM). However objective data about obstructive sleep apnea (OSA) is still limited. The aims of this study were to investigate the frequency of OSA in symptomatic children with CFM and to determine improvement in severity of OSA after treatment.Symptomatic children with CFM referred for a diagnostic polysomnogram (PSG) were identified. Obstructive sleep apnea was defined as an apnea/hypopnea index (AHI) ≥ 1, with moderate/severe OSA as an AHI ≥ 5.Overall, 151 symptomatic children were identified; 87% were diagnosed with OSA, of whom 24% had moderate-to-severe OSA. Children with syndromic CFM, compared to non-syndromic CFM, were more likely to have an AHI ≥ 5 (syndromic 33% vs. non-syndromic 15%, p = 0.02). Of the 131 children with OSA, 64 were treated and 32 returned for a posttreatment PSG, with 22 treated with either positive airway pressure (PAP) or adenotonsillectomy (AT). Children treated with PAP demonstrated a decrease in AHI from 6.2 to 3.5 (p = 0.057) and an increase in SpO2 from 89.1% to 91.1% (p = 0.091). There were no significant improvements for those in the AT group for either AHI (2.5 to 1.8, p = 0.19) or SpO2 (90.4% to 91.3%, p = 0.46). Normalization of the AHI (AHI1) occurred in only one child in each group (7% and 14% of the PAP and AT groups, respectively).The vast majority of children with CFM referred for OSA evaluation are found to have objective evidence of OSA and a quarter of children have moderate-to-severe OSA. It is likely that many children with underlying OSA are not identified and referred for evaluation. Residual OSA after treatment is common in children with CFM. |
| Databáze: | OpenAIRE |
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