Plantago lanceolata L. water extract induces transition of fibroblasts into myofibroblasts and increases tensile strength of healing skin wounds
| Autor: | Vlasta Peržeľová, František Sabol, Ivan Kováč, Emil Švajdlenka, Jaroslav Legáth, Martin Hollý, Ján Ďurkáč, Pavel Mučaji, Karel Smetana, Petr Gál, Katarina Jakubcova, Jozef Belák |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty Contraction (grammar) Skin wound Pharmaceutical Science law.invention Extracellular matrix Rats Sprague-Dawley law Tensile Strength Ultimate tensile strength medicine Animals Plantago lanceolata L Myofibroblasts Plantago Pharmacology Wound Healing integumentary system Dose-Response Relationship Drug Chemistry Plant Extracts Rats Phytotherapy Wound healing Myofibroblast |
| Zdroj: | The Journal of pharmacy and pharmacology. 67(1) |
| ISSN: | 2042-7158 |
| Popis: | Objectives Although the exact underlying mechanisms are still unknown, Plantago lanceolata L. (PL) water extracts are frequently used to stimulate wound healing and to drain abscesses. Therefore, in this experimental study the effect of PL water extract on skin wound healing was studied in Sprague-Dawley rats. Methods Two excisional and one incisional skin wounds were performed on the back of each rat. Wounds were treated for three consecutive days with two different concentrations of the aqueous extract of PL. Rats were sacrificed 7, 14, and 21 days after surgery. Samples of wounds were processed for macroscopic (excisions – wound contraction measurement), biomechanical (incisions – wound tensile strength (TS) measurement) and histological examination (excisions). Key findings It was shown that open wounds treated with PL extract contained myofibroblasts and demonstrated significantly higher contraction rates. Furthermore, significantly increased wound TSs were recorded in treated rats as a consequence of increased organization of extracellular matrix proteins, such as the collagen type 1. Conclusions We demonstrated that PL aqueous extract improves skin wound healing in rats. However, further research need to be performed to find optimal therapeutic concentration, and exact underlying mechanism prior obtained results may be introduced into the clinical practice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text