HTLV-positive adult T-cell leukaemia/lymphoma with Epstein-Barr virus and hepatitis B coinfection
| Autor: | Mihir Raval, Chunlai Zuo, Ayesha Munir, M Kristina Subik |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Epstein-Barr Virus Infections Hepatitis B virus Herpesvirus 4 Human viruses Population Adult T-cell leukaemia/lymphoma Unusual Association of Diseases/Symptoms 030105 genetics & heredity medicine.disease_cause Malignancy Virus 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases Medicine Humans Leukemia-Lymphoma Adult T-Cell education education.field_of_study Human T-lymphotropic virus 1 business.industry Coinfection General Medicine Hepatitis B medicine.disease Epstein–Barr virus Virology HTLV-I Infections Lymphoma business 030217 neurology & neurosurgery |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| Popis: | Human T-cell lymphotropic virus (HTLV) is a human oncoretrovirus known to cause adult T-cell leukaemia/lymphoma (ATLL). Coinfection of human T-lymphotropic virus type 1 with Epstein-Barr virus (EBV) results in enhanced expression of the HTLV virus and leads to aggressive organ involvement from T-cell malignancy. It has also been observed that the prevalence of hepatitis B infection has been higher in patients with HTLV ATLL as compared with the general population in certain countries. We describe a case of a 34-year-old man who initially presented with leucocytosis, fatigue and conjunctival erythema. His radiological images revealed significant generalised adenopathy, and his flow cytometry analysis came back positive for CD4-positive T-cell lymphoma. He was subsequently diagnosed with HTLV-positive ATLL. Ultimately the patient was also diagnosed with acute hepatitis B and EBV. We describe a unique case of ATLL with coinfection with two other viruses, the association of which can be of potential prognostic value in guiding the treatment strategies for ATLL. |
| Databáze: | OpenAIRE |
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