Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project
| Autor: | Sangmin Lee, Joy Pader, Dylan E O'Sullivan, Darren R. Brenner, Amy Metcalfe, Will D. King, Troy W. R. Hillier |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Population level Colorectal cancer Science Health Behavior Article Alberta 03 medical and health sciences Risk-Taking Cancer epidemiology 0302 clinical medicine Risk groups Surveys and Questionnaires Environmental health Humans Medicine 030212 general & internal medicine Life Style Proportional Hazards Models Multidisciplinary Risk behaviour business.industry Hazard ratio Middle Aged medicine.disease Hazard Obesity Latent class model Risk factors 030220 oncology & carcinogenesis Female Colorectal Neoplasms business Risk Reduction Behavior |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | The objective of this study was to identify distinct clusters of individuals that exhibit unique patterns of modifiable lifestyle-related behaviours and to determine how these patterns are associated with the risk of developing colorectal cancer (CRC). The study consisted of 26,460 participants and 267 CRC cases from Alberta’s Tomorrow Project. Exploratory latent class analysis of risk behaviours (obesity, physical inactivity, meat consumption, smoking, alcohol consumption, and fruit and vegetable consumption) and Cox proportional hazard models were utilized. Seven unique behavioural groups were identified, where the risk of CRC was 2.34 to 2.87 times greater for high risk groups compared to the low risk group. Sex-specific models identified higher risk groups among men (Hazard Ratios [HRs]: 3.15 to 3.89) than among women (HRs: 1.99 to 2.19). Targeting groups defined by clustering of behaviours could potentially lead to more effective prevention of CRC on a population level. |
| Databáze: | OpenAIRE |
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