Efficacy of Prophylactic Dexmedetomidine in Preventing Postoperative Junctional Ectopic Tachycardia After Pediatric Cardiac Surgery

Autor: Wael El‐Feky, Samir Hassan, Mohamed El-Kashlan, Mohamed El-Sanosy, Doaa El Amrousy, Nagat S. Elshmaa, Shimaa Elrifaey, Nahed Mohammed Hablas
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Heart Defects
Congenital
Male
Expression of Concern
medicine.medical_specialty
030204 cardiovascular system & hematology
Arrhythmias
03 medical and health sciences
Electrocardiography
0302 clinical medicine
Postoperative Complications
children
Heart Rate
Tachycardia
Ectopic Junctional
Junctional ectopic tachycardia
Adrenergic alpha-2 Receptor Agonists
Medicine
Humans
Arrhythmia and Electrophysiology
Prospective Studies
Dexmedetomidine
Cardiac Surgical Procedures
Infusions
Intravenous
postoperative junctional ectopic tachycardia
Original Research
Cardiopulmonary Resuscitation and Emergency Cardiac Care
Dose-Response Relationship
Drug
business.industry
Infant
dexmedetomidine
medicine.disease
Cardiac surgery
Surgery
Treatment Outcome
030228 respiratory system
Anesthesia
Female
Cardiology and Cardiovascular Medicine
business
medicine.drug
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
ISSN: 2047-9980
Popis: Background Postoperative junctional ectopic tachycardia is one of the most serious arrhythmias that occur after pediatric cardiac surgery, difficult to treat and better to be prevented. Our aim was to assess the efficacy of prophylactic dexmedetomidine in preventing junctional ectopic tachycardia after pediatric cardiac surgery. Methods and Results A prospective controlled study was carried out on 90 children who underwent elective cardiac surgery for congenital heart diseases. Patients were randomized into 2 groups. Group I (dexmedetomidine group): 60 patients received dexmedetomidine; Group II (Placebo group): 30 patients received the same amount of normal saline intravenously. The primary outcome was the incidence of postoperative junctional ectopic tachycardia. Secondary outcomes included bradycardia, hypotension, vasoactive inotropic score, ventilation time, pediatric cardiac care unit stay, length of hospital stay, and perioperative mortality. The incidence of junctional ectopic tachycardia was significantly reduced in the dexmedetomidine group (3.3%) compared with the placebo group (16.7%) with P P P P >0.005). Conclusion Prophylactic use of dexmedetomidine is associated with significantly decreased incidence of postoperative junctional ectopic tachycardia in children after congenital heart surgery without significant side effects.
Databáze: OpenAIRE
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