Fabrication of chitosan-polyethylene glycol nanocomposite films containing ZIF-8 nanoparticles for application as wound dressing materials
| Autor: | Saeed-Reza Pakzad, Javad Malakootikhah, Iradj Ashrafi Tamai, Azin Mazloom-Jalali, Zahra Shariatinia |
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| Rok vydání: | 2020 |
| Předmět: |
Nanoparticle
02 engineering and technology Polyethylene glycol Biochemistry Cell Line Nanocomposites Polyethylene Glycols Chitosan 03 medical and health sciences chemistry.chemical_compound Mice Structural Biology Ultimate tensile strength PEG ratio medicine Animals Molecular Biology 030304 developmental biology chemistry.chemical_classification 0303 health sciences Nanocomposite Bacteria Membranes Artificial General Medicine Polymer Fibroblasts 021001 nanoscience & nanotechnology Bandages Anti-Bacterial Agents chemistry Swelling medicine.symptom 0210 nano-technology Nuclear chemistry |
| Zdroj: | International journal of biological macromolecules. 153 |
| ISSN: | 1879-0003 |
| Popis: | Biocompatible nanocomposite films based on chitosan (CS) and polyethylene glycol (PEG) polymers containing cephalexin (CFX) antibiotic drug and zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (NPs) were designed and fabricated to develop wound dressing materials capable of controlled drug release. Swelling experiment was performed in three acidic, neutral, and alkaline solutions. The tensile strength test reflected that upon increasing the NPs loading within the films, the tensile strength was enhanced but the elongation at break was diminished. The release of the CFX was intensively increased within approximately 3, 8, and 10 h (burst release) in acidic, neutral, and alkaline media, respectively while after that the CFX was smoothly released over time (sustained release). The antibacterial activities of all films were examined against Gram-positive (S. aureus, B. cereus) and Gram-negative (E. coli, P. aeruginosa, and Acinetobacter) bacteria frequently found in the infected wounds. Moreover, the MTT assay revealed that all films had high cell viabilities towards the L929 fibroblast cells confirming these nanocomposites could be used as favorable wound dressing materials. Finally, the film containing 4% ZIF-8 NPs (film 5) was chosen as the best sample due to it revealed appropriate mechanical properties, swelling, drug release and cell viability among all samples examined. |
| Databáze: | OpenAIRE |
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