Magnetic Manipulation of Blood Conductivity with Superparamagnetic Iron Oxide-Loaded Erythrocytes
| Autor: | Bernhard Gleich, Genaro A Paredes-Juarez, Gavin R Philips, Antonella Antonelli, Mauro Magnani, Jeff W.M. Bulte |
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| Rok vydání: | 2019 |
| Předmět: |
Helmholtz coil
Erythrocytes Materials science Field (physics) 02 engineering and technology Conductivity Ferric Compounds Signal Article 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Microscopy Electron Transmission Humans General Materials Science Magnetite Nanoparticles Cells Cultured blood conductivity blood conductivity iron oxide nanoparticles red blood cells Electric Conductivity iron oxide nanoparticles 021001 nanoscience & nanotechnology Magnetic Fields chemistry Tissue Array Analysis Modulation Electrode 0210 nano-technology Iron oxide nanoparticles red blood cells Biomedical engineering Superparamagnetism |
| Zdroj: | ACS Applied Materials & Interfaces. 11:11194-11201 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.9b00394 |
| Popis: | The active and passive electrophysiological properties of blood and tissue have been utilized in a vast array of clinical techniques to noninvasively characterize anatomy and physiology and to diagnose a wide variety of pathologies. However, the accuracy and spatial resolution of such techniques are limited by several factors, including an ill-posed inverse problem, which determines biological parameters and signal sources from surface potentials. Here, we propose a method to noninvasively modulate tissue conductivity by aligning superparamagnetic iron oxide-loaded erythrocytes with an oscillating magnetic field. A prototype device is presented, which incorporates a three-dimensional set of Helmholtz coil pairs and fluid-channel-embedded electrode arrays. Alignment of loaded cells (∼11 mM iron) within a field of 12 mT is demonstrated, and this directed reorientation is shown to alter the conductivity of blood by ∼5 and ∼0.5% for stationary and flowing blood, respectively, within fields as weak as 6-12 mT. Focal modulation of conductivity could drastically improve numerous bioimpedance-based detection modalities. |
| Databáze: | OpenAIRE |
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