Biological significance of miR-126 expression in atrial fibrillation and heart failure

Autor: R.S. Xie, X.J. Wei, G.C. Wei, M. Han, Z.G. Liang, Y. Tian, F.Y. Yang, C.L. Gong, C.W. Ji, H. Yao
Rok vydání: 2015
Předmět:
Male
Medicine (General)
MicroRNA-126
Physiology
N-terminal prohormone brain natriuretic peptide (NT-proBNP)
Prohormone
Biochemistry
Ventricular Function
Left
Natriuretic Peptide
Brain
Biology (General)
General Pharmacology
Toxicology and Pharmaceutics
lcsh:QH301-705.5
Aged
80 and over
lcsh:R5-920
Ejection fraction
General Neuroscience
Atrial fibrillation
General Medicine
Middle Aged
Atrial Function
Prognosis
Brain natriuretic peptide
Cardiology
Biomarker (medicine)
Female
Multiple linear regression analysis
lcsh:Medicine (General)
medicine.drug
Adult
medicine.medical_specialty
QH301-705.5
Immunology
Biophysics
Heart failure
Ocean Engineering
Real-Time Polymerase Chain Reaction
R5-920
Internal medicine
medicine
Humans
Heart function indices
Aged
business.industry
Biomedical Sciences
Cell Biology
medicine.disease
Peptide Fragments
MicroRNAs
lcsh:Biology (General)
Biological significance
Linear Models
business
Biomarkers
Zdroj: Brazilian Journal of Medical and Biological Research v.48 n.11 2015
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 48, Iss 11, Pp 983-989 (2015)
Brazilian Journal of Medical and Biological Research, Volume: 48, Issue: 11, Pages: 983-989, Published: 25 AUG 2015
ISSN: 1414-431X
0100-879X
DOI: 10.1590/1414-431x20154590
Popis: We investigated the biological significance of microRNA-126 (miR-126) expression in patients with atrial fibrillation (AF) and/or heart failure (HF) to examine the possible mechanism of miR-126-dependent AF and development of HF. A total of 103 patients were divided into three groups: AF group (18 men and 17 women, mean age: 65.62±12.72 years), HF group (17 men and 15 women, mean age: 63.95±19.71 years), and HF-AF group (20 men and 16 women, mean age: 66.56±14.37 years). Quantitative real-time PCR was used to measure relative miR-126 expression as calculated by the 2−ΔΔCt method. miR-126 was frequently downregulated in the 3 patient groups compared with controls. This reduction was significantly lower in permanent and persistent AF patients than in those with paroxysmal AF (P
Databáze: OpenAIRE
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