A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

Autor: George R. Marcotte, Marissa Z. McMackin, Keith Baar, Gino A Cortopassi, Fawaz G. Haj, Alexey Tomilov, Stephen M Griffey, Zeyu Zhou, Shinichiro Koike, Jon J. Ramsey, Kyoungmi Kim, Kevork Hagopian, Jose Alberto Lopez-Dominguez, Marita A. Wallace, Dianna Tran, Denise M. Imai, Gabriella Perez, Megan N. Roberts, Trina A. Knotts, Elena Gutiérrez-Casado
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Aging
Ketogenic
ketones
Physiology
medicine.medical_treatment
healthspan
Medical Biochemistry and Metabolomics
Inbred C57BL
memory
Diet
Carbohydrate-Restricted
Mice
low-carbohydrate diet
0302 clinical medicine
Glycolysis
media_common
Physiological function
Longevity
Acetylation
Adaptation
Physiological
Organ Specificity
Health
ketogenic diet
Ketone bodies
Zero Hunger
Diet
Ketogenic
lifespan
Signal Transduction
medicine.medical_specialty
beta-hydroxybutyrate
media_common.quotation_subject
Physiological
1.1 Normal biological development and functioning
Calorie restriction
Biology
Mechanistic Target of Rapamycin Complex 1
Article
03 medical and health sciences
Endocrinology & Metabolism
Underpinning research
Internal medicine
Complementary and Integrative Health
medicine
Animals
Adaptation
Molecular Biology
Nutrition
Carbohydrate-Restricted
Cell Biology
medicine.disease
Diet
Mice
Inbred C57BL
Malnutrition
030104 developmental biology
Endocrinology
ketone bodies
Protein Acetylation
Biochemistry and Cell Biology
030217 neurology & neurosurgery
Ketogenic diet
Zdroj: Cell metabolism, vol 26, iss 3
Popis: Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this metabolic shift using low-carbohydrate diets and to determine the influence of these diets on longevity and healthspan in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control diet at 12months of age and were either allowed to live theirnatural lifespan or tested for physiological function after 1 or 14months of dietary intervention. The ketogenic diet (KD) significantly increased median lifespan and survival compared to controls. In aged mice, only those consuming a KD displayed preservation of physiological function. The KD increased protein acetylation levels and regulated mTORC1 signaling in a tissue-dependent manner. This study demonstrates that a KD extends longevity and healthspan in mice.
Databáze: OpenAIRE
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