Evidence for vesicle formation from 1:1 nonionic surfactant span 60 and fatty alcohol mixtures in aqueous ethanol: potential delivery vehicle composition
| Autor: | N.S. Neeta, Prasun Bandyopadhyay |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Chromatography
Ethanol Vesicle Fatty alcohol Water Sorbitan Alcohol Surfaces and Interfaces General Medicine Surface tension chemistry.chemical_compound Colloid and Surface Chemistry Drug Delivery Systems chemistry Dynamic light scattering Stearate Drug delivery Liposomes Physical and Theoretical Chemistry Fatty Alcohols Biotechnology Hexoses |
| Zdroj: | Colloids and surfaces. B, Biointerfaces. 58(2) |
| ISSN: | 0927-7765 |
| Popis: | A study of the self-organization of nonionic surfactant span 60 (sorbitan mono stearate) in presence of fatty alcohol (stearyl, cetyl and lauryl) is presented. When ethanolic solution of the surfactant-fatty alcohol (1:1) mixture is added in water spontaneous large unilamellar vesicles (LUV) are formed which may potentially be useful vehicles for drug delivery purposes. Vesicular suspension has been characterized by transmission electron microscopy, dynamic light scattering, confocal laser scanning microscopy, dye entrapment and release studies. Surface tension measurement indicates the suitability of fatty alcohols towards spontaneous vesicle formation from span 60. |
| Databáze: | OpenAIRE |
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