Abnormal cardiac enzymes in systemic sclerosis: a report of four patients and review of the literature
| Autor: | V Flower, Chiara Bucciarelli-Ducci, Bhavisha Vasta, E. Korendowych, John D Pauling, Sue Brown, Neil McHugh |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart Diseases medicine.medical_treatment Disease Troponin T Rheumatology Internal medicine medicine Humans Pericardium Aged Subclinical infection Scleroderma Systemic integumentary system biology business.industry Myocardium food and beverages Heart Immunosuppression General Medicine Middle Aged Troponin Coronary arteries medicine.anatomical_structure cardiovascular system biology.protein Cardiology Female business |
| Zdroj: | Clinical Rheumatology. 33:435-438 |
| ISSN: | 1434-9949 0770-3198 |
| Popis: | Cardiac involvement in systemic sclerosis (SSc) is heterogeneous and can include primary involvement of the myocardium, pericardium and coronary arteries or be secondary to cardiac complications of pulmonary and renal disease. Primary cardiac involvement in SSc is uncommon but can result in ventricular dysfunction, organ failure, arrhythmias and death. It can remain clinically silent and the prevalence is likely to be under-reported. We report four cases of SSc associated with a raised serum troponin T (TnT), in a proportion of whom cardiac MRI myocardial abnormalities were detected. These cases highlight the heterogeneity of cardiac involvement in SSc, the role of cardiac MRI and promising biochemical responses to immunosuppression. Cardiac biomarkers such as TnT may be useful screening tools to identify subclinical cardiac disease and assess response to therapeutic intervention. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink