Synthesis, Analgesic and Anti-Inflammatory Evaluation of Some New 3H-Quinazolin-4-one Derivatives
| Autor: | Adel S. El-Azab, Mohamad-Hesham Y. Daba, Adnan A. Kadi, Ahmed M. Alafeefy, Sami G. Abdel-Hamide |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Spectrophotometry Infrared medicine.drug_class Analgesic Pain Pharmaceutical Science Oxadiazole Pharmacology Carrageenan Mass Spectrometry Anti-inflammatory Mice Structure-Activity Relationship chemistry.chemical_compound Edema Drug Discovery medicine Animals Rats Wistar Acetic Acid Pain Measurement Quinazolinones Analgesics Anti-Inflammatory Agents Non-Steroidal Rats chemistry Quinazolin-4-one Female medicine.symptom |
| Zdroj: | Archiv der Pharmazie. 341:377-385 |
| ISSN: | 1521-4184 0365-6233 |
| DOI: | 10.1002/ardp.200700271 |
| Popis: | In this study, we have synthesized a series of 3H-quinazolin-4-ones in order to obtain new compounds with potential analgesic and anti-inflammatory activity. The structures of the newly synthesized compounds were confirmed by means of infrared, nuclear magnetic resonance and mass spectroscopy. Some compounds were evaluated for their analgesic and anti-inflammatory activities by writhing and carrageenan-induced rat paw edema tests, respectively. In comparison to the standard drug indomethacine, compounds 4, 6c, 12-14, 16, 18, 19, and 22 induced significant reduction in the writhing response while compounds 6c, 12, 14, 16, 18, and 22 produced a good dose-dependent anti-inflammatory activity. The best dual analgesic / anti-inflammatory relative activity was observed with compounds 6c, 14, 16, 18, and 22. |
| Databáze: | OpenAIRE |
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