Nitric oxide synthase (NOS) in schizophrenia
| Autor: | W. S. T. Griffin, N. C. Moore, W. Q. Sturner, Ted M. Dawson, Mohammed Husain, Robert E. Mrak, Solomon H. Snyder, Craig N. Karson |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Cerebellum Psychosis medicine.medical_specialty Tegmentum Mesencephali Reference Values Internal medicine medicine Tegmentum Humans Molecular Biology Aged Mesopontine Aged 80 and over Neurons biology General Neuroscience NADPH Dehydrogenase Organ Size Middle Aged medicine.disease Nitric oxide synthase medicine.anatomical_structure Endocrinology Nerve growth factor Schizophrenia Cerebellar vermis biology.protein Female Neurology (clinical) Brainstem Nitric Oxide Synthase Antipsychotic Agents Brain Stem |
| Zdroj: | Molecular and Chemical Neuropathology. 27:275-284 |
| ISSN: | 1044-7393 |
| DOI: | 10.1007/bf02815109 |
| Popis: | A high proportion of neurons in the cerebellum and in cholinergic brainstem nuclei stain positive for nicotinamide adenine dinucleotide phosphate-diaphorase (NADPHd), which is a nitric oxide synthase (NOS). Recent evidence suggests that schizophrenia may involve increased numbers of NADPHd-stained neurons in different areas of the subcortex. This led us to examine the actual concentration of NOS in postmortem brain specimens of cerebellum, and the relevant regions of brainstem tegmentum, to see if NOS concentrations were also increased in schizophrenia. Postmortem rain tissue was obtained at autopsy from schizophrenics and controls who did not have other brain disease. In patients with schizophrenia, NOS concentration was increased in the cerebellum (0.62±0.31 vs 0.32±0.27 absorption intensity or AI,p |
| Databáze: | OpenAIRE |
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