HLA Class I Antigens in Japanese Patients with Melanoma
| Autor: | Yoshiaki Hori, Motomi Miyahara, Kazuhito Hayashibe, Taeko K. Naruse, Akira Ozawa, Hidemi Nakagawa, Juichiro Nakayama, Masamitsu Ichihashi, Hidetoshi Inoko, Shunji Hirai, Takashi Horikoshi, Kunihiko Tamaki, Muneo Ohkido, Tomomichi Ono, Toshiro Kageshita |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Cancer Research Skin Neoplasms Immunology Human leukocyte antigen Mongoloid Biology Serology Gene Frequency Japan HLA Antigens Polymorphism (computer science) medicine Humans Immunology and Allergy Allele Melanoma Allele frequency Alleles Aged Aged 80 and over Pharmacology Polymorphism Genetic Histocompatibility Antigens Class I Middle Aged medicine.disease Clinical trial Female |
| Zdroj: | Journal of Immunotherapy. 19:428-432 |
| ISSN: | 1524-9557 |
| Popis: | In this study, we analyzed the frequencies of human leukocyte antigen (HLA) class I alleles in 110 Japanese patients with melanoma using serological methods, and compared such frequencies with clinical parameters. As expected, frequencies of HLA allele distribution in patients with melanoma reflected the frequencies observed in the normal Japanese population. Because these are different from populations belonging to other races (e.g., white), it followed that the HLA allele distribution in melanoma patients varies among different races. This differences may have significant implications for T-cell-mediated, HLA-restricted therapeutic modalities. No significant associations between HLA and clinical parameters were noted in this study. This report may help design future clinical trials involving therapeutic approaches based on HLA-restricted mechanisms. |
| Databáze: | OpenAIRE |
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