SARS- CoV-2 infection and oxidative stress in early-onset preeclampsia

Autor: Reinaldo Marín, Flor H. Pujol, Deliana Rojas, Luis Sobrevia
Jazyk: angličtina
Rok vydání: 2021
Předmět:
TNF-α
tumour necrosis factor-alpha
Placenta
TMPRSS2
transmembrane serine protease type 2
HIF-1α
hypoxia-inducible factor 1 alpha
Ang 1–7
angiotensin 1-7
IL-8
interleukin 8
TNF
tumour necrosis factor
HIF-2α
hypoxia-inducible factor 2 alpha
AT1
angiotensin receptor 1
Pre-Eclampsia
Pregnancy
reproductive and urinary physiology
COVID-19
coronavirus disease 2019
loPE
late-onset preeclampsia
PlGF
placental growth factor
VEGF
vascular endothelial growth factor
IL-6
interleukin 6
sFlt-1
soluble fms-like tyrosine kinase-1
H2O2
hydrogen peroxide
Molecular Medicine
Female
1O2
singlet oxygen
Human
ACE
angiotensin-converting enzyme
NADH
nicotinamide adenine dinucleotide reduced form
CTB
cytotrophoblast
ACE2
angiotensin-converting enzyme 2
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
Article
ROS
reactive oxygen species
•OH
hydroxyl radicals
SOD
superoxide dismutase
•O2−
superoxide anion
Animals
Humans
STB
syncytiotrophoblast
Molecular Biology
Ang II
angiotensin II
eoPE
early-onset preeclampsia
NF-κB
nuclear transcription factor-kappa B
SARS-CoV-2
COVID-19
RAS
renin-angiotensin system
NADPH
nicotinamide adenine dinucleotide phosphate
Preeclampsia
ONOO−
peroxynitrite
Oxidative Stress
NO•
nitric oxide
IL-10
interleukin 10
ADAM17
a disintegrin and metalloprotease 17
CAT
catalase
Zdroj: Biochimica et Biophysica Acta. Molecular Basis of Disease
ISSN: 1879-260X
0925-4439
Popis: SARS-CoV-2 causes coronavirus disease 2019 (COVID-19) also in pregnant women. Infection in pregnancy leads to maternal and placental functional alterations. Pregnant women with vascular defects such as preeclampsia show high susceptibility to SARS-CoV-2 infection by undefined mechanisms. Pregnant women infected with SARS-CoV-2 show higher rates of preterm birth and caesarean delivery, and their placentas show signs of vasculopathy and inflammation. It is still unclear whether the foetus is affected by the maternal infection with this virus and whether maternal infection associates with postnatal affections. The SARS-CoV-2 infection causes oxidative stress and activation of the immune system leading to cytokine storm and next tissue damage as seen in the lung. The angiotensin-converting-enzyme 2 expression is determinant for these alterations in the lung. Since this enzyme is expressed in the human placenta, SARS-CoV-2 could infect the placenta tissue, although reported to be of low frequency compared with maternal lung tissue. Early-onset preeclampsia (eoPE) shows higher expression of ADAM17 (a disintegrin and metalloproteinase 17) causing an imbalanced renin-angiotensin system and endothelial dysfunction. A similar mechanism seems to potentially account for SARS-CoV-2 infection. This review highlights the potentially common characteristics of pregnant women with eoPE with those with COVID-19. A better understanding of the mechanisms of SARS-CoV-2 infection and its impact on the placenta function is determinant since eoPE/COVID-19 association may result in maternal metabolic alterations that might lead to a potential worsening of the foetal programming of diseases in the neonate, young, and adult.
Databáze: OpenAIRE
Externí odkaz: