Predictive Validity of the qSOFA Score for Sepsis in Adults with Community-Onset Staphylococcal Infection in Thailand
| Autor: | Ploenchan Chetchotisakd, Kristina E. Rudd, Pornpan Suntornsut, T.E. West, Derek C. Angus, Sharon J. Peacock, Sarunporn Tandhavanant, Supaksh Gupta, Narisara Chantratita |
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| Přispěvatelé: | Gupta, Supaksh [0000-0001-9431-5326], Rudd, Kristina E [0000-0002-6695-8401], Angus, Derek C [0000-0002-7026-5181], West, Timothy Eoin [0000-0001-5503-7204], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Predictive validity
medicine.medical_specialty Staphylococcus Population lcsh:Medicine Logistic regression Article Sepsis sepsis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine sequential organ failure assessment scores 030212 general & internal medicine 10. No inequality education Community onset education.field_of_study Receiver operating characteristic business.industry lcsh:R 030208 emergency & critical care medicine General Medicine medicine.disease Thailand 3. Good health Systemic inflammatory response syndrome systemic inflammatory response syndrome Cohort business |
| Zdroj: | Journal of Clinical Medicine Volume 8 Issue 11 Journal of Clinical Medicine, Vol 8, Iss 11, p 1908 (2019) |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm8111908 |
| Popis: | The quick sequential organ failure assessment (qSOFA) score has had limited validation in lower resource settings and was developed using data from high-income countries. We sought to evaluate the predictive validity of the qSOFA score for sepsis within a low- and middle-income country (LMIC) population with culture-proven staphylococcal infection. This was a secondary analysis of a prospective multicenter cohort in Thailand with culture-positive infection due to Staphylococcus aureus or S. argenteus within 24 h of admission and positive (&ge 2/4) systemic inflammatory response syndrome (SIRS) criteria. Primary exposure was maximum qSOFA score within 48 h of culture collection and primary outcome was mortality at 28 days. Baseline risk of mortality was determined using a multivariable logistic regression model with age, gender, and co-morbidities significantly associated with the outcome. Predictive validity was assessed by discrimination of mortality using area under the receiver operating characteristic (AUROC) curve compared to a model using baseline risk factors alone. Of 253 patients (mean age 54 years (SD 16)) included in the analysis, 23 (9.1%) died by 28 days after enrollment. Of those who died, 0 (0%) had a qSOFA score of 0, 8 (35%) had a score of 1, and 15 (65%) had a score &ge 2. The AUROC of qSOFA plus baseline risk was significantly greater than for the baseline risk model alone (AUROCqSOFA = 0.80 (95% CI, 0.70&ndash 0.89), AUROCbaseline = 0.62 (95% CI, 0.49&ndash 0.75) p < 0.001). Among adults admitted to four Thai hospitals with community-onset coagulase-positive staphylococcal infection and SIRS, the qSOFA score had good predictive validity for sepsis. |
| Databáze: | OpenAIRE |
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