Immunoprophylactic strategies against respiratory influenza virus infection
| Autor: | Deana Sabuda, Colin Crist, Edward G. Saravolac, Huiming Yang, Glen Schnell, Hilton B Levy, Meir Kende, Karen Blasetti, Jonathan P. Wong |
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| Rok vydání: | 2001 |
| Předmět: |
Time Factors
medicine.medical_treatment Orthomyxoviridae Antibodies Viral Virus Interferon-gamma Mice Immune system Adjuvants Immunologic Influenza Human medicine Animals Humans Administration Intranasal General Veterinary General Immunology and Microbiology biology Immunization Passive Public Health Environmental and Occupational Health Antiviral antibody Immunotherapy biology.organism_classification Virology Recombinant Proteins Poly I-C Infectious Diseases Liposomes Immunology biology.protein Molecular Medicine Nasal administration Viral disease Antibody |
| Zdroj: | Vaccine. 19:2227-2232 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/s0264-410x(00)00450-3 |
| Popis: | The objective of this report is to evaluate the prophylactic efficacy of liposome-mediated immunotherapy for prevention of respiratory influenza virus infection in mice. Antiviral antibody, interferon-gamma and poly (ICLC) were encapsulated in liposomes and they were evaluated for their ability to induce protective immunity against lethal influenza infection. Passive immunization using liposome-encapsulated antiviral antibody was found to offer complete protection against the virus challenge. However, this pretreatment must be administered within 24 h prior to virus challenge to be protective. Pretreatment with liposome-encapsulated interferon-gamma was found to stimulate cellular immune responses, but the protection is partial. Immunoprophylaxis using liposome-encapsulated double-stranded (ds) RNA poly (ICLC) provided complete and longer-lasting protection against influenza infection. These results suggest liposome-mediated immunoprophylactic approaches are effective in the prevention of respiratory influenza virus infection. |
| Databáze: | OpenAIRE |
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