Effects of post-ovariectomy time frame and age on the antidepressant-like actions of estradiol and prolame in female rats

Autor:	Olivia Tania, Hernández-Hernández, José Jaime, Herrera-Pérez, Roberto, Chavira, Cristina, Lemini, Lucía, Martínez-Mota
Rok vydání:	2022
Předmět:	Behavioral Neuroscience Endocrinology Estradiol Endocrine and Autonomic Systems Ovariectomy Animals Humans Estrogens Female Estrenes Rats Wistar Antidepressive Agents Rats
Zdroj:	Hormones and Behavior. 141:105154
ISSN:	0018-506X
DOI:	10.1016/j.yhbeh.2022.105154
Popis:	Estrogen replacement therapy (ERT) is an effective treatment for symptoms associated with climacteric and depression some women experience during perimenopause and menopause. The antidepressant-like effects of ERT may depend on the type of estrogen, age, and time when restitution is initiated after hormonal decline. Prolame is a synthetic steroid with estrogenic and antidepressant-like effects that may produce fewer adverse effects. We hypothesize that such actions of prolame on females depend on age and the duration of hormone deprivation period. We assessed the antidepressant-like effects of 17β-estradiol (E
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f683be503b0e15a4ffa8ef285feb5ff https://doi.org/10.1016/j.yhbeh.2022.105154 Zobrazit plný text záznamu Full Text from ScienceDirect