Genetic sharing with coronary artery disease identifies potential novel loci for bone mineral density
| Autor: | Xu Lin, Kuan-Jui Su, Chun-Ping Zeng, Wei-Feng Deng, Jonathan Greenbaum, Feng Liu, Jie Shen, Wei Zhu, Cheng Peng, Hong-Wen Deng, Hui-Ling Lou |
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| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine False discovery rate Histology Physiology Endocrinology Diabetes and Metabolism Osteoporosis 030209 endocrinology & metabolism Single-nucleotide polymorphism Genome-wide association study Coronary Artery Disease Biology Polymorphism Single Nucleotide Article 03 medical and health sciences 0302 clinical medicine Bone Density Pleiotropy Missing heritability problem medicine Humans Genetic Predisposition to Disease Genetic variability KEGG Genetics Genetic Pleiotropy medicine.disease 030104 developmental biology Genome-Wide Association Study |
| Zdroj: | Bone. 103:70-77 |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/j.bone.2017.06.016 |
| Popis: | Bone mineral density (BMD) is a complex trait with high missing heritability. Numerous evidences have shown that BMD variation has a relationship with coronary artery disease (CAD). This relationship may come from a common genetic basis called pleiotropy. By leveraging the pleiotropy with CAD, we may be able to improve the detection power of genetic variants associated with BMD. Using a recently developed conditional false discovery rate (cFDR) method, we jointly analyzed summary statistics from two large independent genome wide association studies (GWAS) of lumbar spine (LS) BMD and CAD. Strong pleiotropic enrichment and 7 pleiotropic SNPs were found for the two traits. We identified 41 SNPs for LS BMD (cFDR |
| Databáze: | OpenAIRE |
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