The value of inflammatory parameters in the prognosis of malignant mesothelioma
| Autor: | Yilmaz Palanci, Abdurrahman Abakay, Özlem Abakay, Abdullah Cetin Tanrikulu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Mesothelioma Pathology medicine.medical_specialty Lung Neoplasms Multivariate analysis Neutrophils Biochemistry Gastroenterology White blood cell Internal medicine medicine Humans Lymphocyte Count Lymphocytes Neutrophil to lymphocyte ratio Retrospective Studies Inflammation Univariate analysis business.industry Mortality rate Mesothelioma Malignant Biochemistry (medical) Asbestos Retrospective cohort study Red blood cell distribution width Environmental Exposure Cell Biology General Medicine Middle Aged Prognosis medicine.disease Survival Rate medicine.anatomical_structure Female business |
| Zdroj: | Journal of International Medical Research. 42:554-565 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/0300060513504163 |
| Popis: | Objective This study investigated the relationship between potential prognostic parameters that may be associated with increased inflammation and survival in patients with malignant mesothelioma (MM). Methods This retrospective study assessed potential prognostic parameters measured at the time of MM diagnosis. Data on asbestos exposure, histopathological subtype of MM and laboratory parameters were collected. Results In 155 patients with MM (90 male), mean survival time was 13.9 months. In univariate analysis, age ≥60 years and neutrophil-to-lymphocyte ratio (NLR) ≥3 were associated with significantly shortened median survival times. In multivariate analysis, nonepithelial subtype, red cell distribution width (RDW) ≥20% and NLR ≥3 were associated with significantly shortened median survival times. Mortality rate was increased 2.77-, 1.67- and 1.52-fold in patients with RDW ≥20%, NLR ≥3 and nonepithelial subtype, respectively. Nonepithelial subtype, white blood cell count ≥11 200 µl and platelet-to-lymphocyte ratio ≥300 at baseline were associated with a heightened NLR value. Conclusions The NLR and RDW were significant predictive factors for MM prognosis. |
| Databáze: | OpenAIRE |
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