CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer
| Autor: | Shunichi Negoro, Noriyuki Masuda, Yoko Kusunoki, Masayuki Nishioka, Kaoru Matsui, Minoru Takada, Shinzoh Kudoh, Masahiro Fukuoka, Nobuhide Takifuji, Kazuhiko Nakagawa |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Vincristine Lung Neoplasms medicine.medical_treatment Drug Resistance Irinotecan Recurrence Internal medicine Humans Medicine Prospective Studies Carcinoma Small Cell Lung cancer Etoposide Aged Cisplatin Chemotherapy business.industry Combination chemotherapy Middle Aged medicine.disease Antineoplastic Agents Phytogenic Survival Analysis Surgery Treatment Outcome Drug Evaluation Camptothecin Female business medicine.drug |
| Zdroj: | Journal of Clinical Oncology. 10:1225-1229 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.1992.10.8.1225 |
| Popis: | PURPOSE To evaluate the activity of CPT-11, which is a new derivative of camptothecin, against refractory or relapsed small-cell lung cancer (SCLC). PATIENTS AND METHODS Sixteen patients with refractory or relapsed SCLC were entered onto a prospective, non-randomized, single-institution phase II trial. All 16 patients had been pretreated heavily with some form of cisplatin-based combination chemotherapy. Five patients had received previous chemotherapy with cisplatin, vincristine, doxorubicin, and etoposide (CODE) as an induction therapy. Six patients had been treated with concurrent cisplatin and etoposide plus chest x-ray. The median time off chemotherapy was 7.3 months (range, 1.9 to 15.1 months). Patients were treated with a CPT-11 starting dose of 100 mg/m2 body surface given as a 90-minute intravenous (IV) infusion every week with subsequent doses based on toxicity. Fifteen patients were assessable for toxicity, response, and survival. RESULTS Seven patients (47%; 95% confidence limits for an overall response rate, 21.4% to 71.9%) responded to CPT-11 with a median duration of response of 58 days. The major toxicities were myelosuppression (predominantly leukopenia), diarrhea, and pulmonary toxicity. CONCLUSION CPT-11 is an active agent against refractory or relapsed SCLC and deserves to be studied more closely as both a single agent and in combination with other drugs to treat patients with SCLC. |
| Databáze: | OpenAIRE |
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