The role of coronary flow and pressure as determinants of myocardial oxygen consumption in the presence or absence of vasomotor tone
| Autor: | Danuta Zborowska-Sluis, Gerald A. Klassen, Richard R. Mildenberger |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Physiology Blood Pressure In Vitro Techniques Coronary pressure Myocardial oxygen consumption Dogs Oxygen Consumption Heart Rate Physiology (medical) Internal medicine Coronary Circulation Renin–angiotensin system medicine Animals Coronary flow Pharmacology business.industry Angiotensin II Myocardium Muscle Smooth General Medicine Dipyridamole Anesthesia Muscle Tonus Cardiology Blood Vessels business human activities Vasomotor tone medicine.drug Oxygen extraction |
| Zdroj: | Canadian journal of physiology and pharmacology. 55(3) |
| ISSN: | 0008-4212 |
| Popis: | When coronary flow was kept constant and coronary pressure increased by angiotensin or decreased by dipyridamole, myocardial oxygen consumption (MVO2) remained unchanged. When vasomotor tone was abolished by dipyridamole or was intact, changing coronary flow resulted in a change in MVO2 in the same direction as flow; this change in MVO2 was in part the result of a significant alteration in coronary oxygen extraction. These results suggest that coronary flow, but not coronary pressure is an important determinant of MVO2 both in the presence or absence of vasomotor tone. |
| Databáze: | OpenAIRE |
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