Un cluster géographique de paralysie supranucléaire progressive dans le nord de la France
| Autor: | Bernard Sablonnière, Claude-Alain Maurage, Valérie Buée-Scherrer, D. Caparros-Lefebvre, Francois Caparros, Andrew Lees, Luc Buée, Vincent Deramecourt, Vincent Huin, Lawrence I. Golbe, Hélène Obriot |
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| Přispěvatelé: | Service de neurologie [Wattrelos], Centre Hospitalier de Wattrelos, Rutgers Robert Wood Johnson Medical School, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Reta Lila Weston Institute for Neurological Studies, Queen Mary University of London (QMUL), HUIN, Vincent |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Textile dyeing Population tau Proteins Article Progressive supranuclear palsy Humans Medicine [SDV.EE.SANT] Life Sciences [q-bio]/Ecology environment/Health [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] education Aged Aged 80 and over [SDV.EE]Life Sciences [q-bio]/Ecology environment [SDV.EE.SANT]Life Sciences [q-bio]/Ecology environment/Health education.field_of_study Movement Disorders [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology business.industry Incidence (epidemiology) Parkinsonism Haplotype Middle Aged medicine.disease Magnetic Resonance Imaging Confidence interval eye diseases 3. Good health [SDV.EE] Life Sciences [q-bio]/Ecology environment Phenotype Haplotypes [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie BALANCE DIFFICULTY Female [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie France Supranuclear Palsy Progressive Neurology (clinical) business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Neurology Neurology, 2015, 85 (15), pp.1293-1300. ⟨10.1212/WNL.0000000000001997⟩ |
| ISSN: | 0028-3878 1526-632X |
| DOI: | 10.1212/WNL.0000000000001997⟩ |
| Popis: | International audience; Objective: To describe a cluster of progressive supranuclear palsy (PSP) in northern France. PSP has not been reported in geographical, temporal, or occupational clusters. A unit of Neurology and Neurogeriatrics opened in 2005 at the Centre Hospitalier de Wattrelos, serving the population of Wattrelos and Leers (combined population 51,551) and parts of neighboring towns. For most of the 20th century, this area was a center for chromate and phosphate ore processing, textile dyeing, and tanning. Significant industrial waste persists close to residential areas. Methods: From 2005 to 2014, 92 patients with PSP at Centre Hospitalier de Wattrelos were identified and studied. Detailed residential data were available in the medical records. Eighty cases have had magnetic resonance head scanning and 60 have died, of whom 13 have been examined neuropathologically. Results: The ratio of observed to expected PSP incidence over the period 2005 to 2012 was 12.3 (95% confidence interval: 7.4–35.9). Mean onset age was 74.3 years. The Richardson syndrome/PSP-parkinsonism ratio was 43%/42%. Four other phenotypes each occurred in 2% to 5%. Onset was gait/balance difficulty in 52%. None of the 92 affected patients were relatives and 7 were of North African ancestry. MRI was compatible with a clinical diagnostic of PSP in all cases. Histopathologic examination confirmed neurofibrillary degeneration and tufted astrocytes in all autopsied cases. Western blots revealed a typical tau 4R doublet. The tau H1 haplotype occurred in 95.8% of cases' chromosomes. Conclusions: We have identified a cluster of PSP in a geographical area with severe environmental contamination by industrial metals. |
| Databáze: | OpenAIRE |
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