Rapidly Progressive Osteoarthrosis of Ochronotic Origin: A Pathologic Study
| Autor: | Danielle Lacotte, Charles-Albert Baud, René Lagier, Timothy Cunningham |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Cartilage
Articular Chondropathy Ochronosis Pathology medicine.medical_specialty Chemistry Cartilage Synovial Membrane General Medicine Anatomy Osteoarthritis medicine.disease Fibril Microscopy Electron Femoral head medicine.anatomical_structure medicine Humans Female Bone Diseases Joint Diseases Synovial membrane Ochronotic arthropathy Aged |
| Zdroj: | American Journal of Clinical Pathology. 90:95-102 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/90.1.95 |
| Popis: | A case of hip osteoarthrosis associated with ochronosis in a 65-year-old woman is reported. Characteristic features of both conditions were observed macroscopically and on light and electron microscopic examination. In the cartilage the pigment deposits were located on and between thick collagen fibrils. In the synovial membrane there were embedded packets of cartilage shards of which the collagen fibrils and pigment were phagocytosed, as well as calcified bone debris whose disaggregation might have explained the presence of some apatite deposits free of any underlying collagen structure. As also previously observed, the present case of ochronotic hip osteoarthrosis is remarkable for the minor osteophyte formation and for the inclusion of pigmented cartilage shards in the osteomedullar remodeled territory. It also demonstrates a collapse of the femoral head cortex presumably related to the rapid clinical and radiologic evolution. By the well-known origin of its chondropathy and by the pigment labeling of the cartilage, ochronotic arthropathy provides an almost experimental model for analyzing a broader problem, i.e ., that of the various components of an osteoarthrotic remodeling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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