Myocardial injury in major aortic surgery
| Autor: | H. M. Hafez, CS Berwanger, A. McColl, Gerard Stansby, John H.N. Wolfe, A. O. Mansfield, William Richmond |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Lipid Peroxides Time Factors Myocardial Infarction Hemodynamics Blood Pressure Myocardial Reperfusion Myocardial Reperfusion Injury Antioxidants law.invention Aortic aneurysm Aneurysm Troponin T law Heart Rate medicine.artery medicine Cardiopulmonary bypass Humans APACHE Aged Aged 80 and over Aorta Analysis of Variance Cardiopulmonary Bypass Aortic Aneurysm Thoracic Vascular disease business.industry Myocardium Middle Aged medicine.disease Oxidative Stress Cardiothoracic surgery Anesthesia Linear Models cardiovascular system Female Surgery business Cardiology and Cardiovascular Medicine Abdominal surgery Aortic Aneurysm Abdominal Follow-Up Studies |
| Zdroj: | Journal of Vascular Surgery. 31(4):742-750 |
| ISSN: | 0741-5214 |
| DOI: | 10.1067/mva.2000.102325 |
| Popis: | Purpose: The purpose of this study was to examine the effects of major aortic surgery and its associated oxidative stress and injury on the myocardium. Methods: Plasma from 27 patients who underwent thoracoabdominal aortic aneurysm (TAAA) repair and 17 patients who underwent infrarenal aortic aneurysm (AAA) repair was collected at incision, aortic crossclamping, and reperfusion and 1, 8, and 24 hours thereafter. Samples were assayed for the myocardial specific protein troponin-T, total antioxidant status, and lipid hydroperoxides. Results: Ten patients experienced cardiac dysfunction in the first 24 hours after surgery (eight patients in the TAAA group and two patients in the AAA group). Immediately after reperfusion, total antioxidant status levels dropped in all patients with TAAA and with AAA; this was more marked in patients with TAAA, leading to a significant difference between the two groups at this time point and for up to 1 hour thereafter (P |
| Databáze: | OpenAIRE |
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