Facile and Novel Synthesis of Spiky Gold Nanoparticles as an Efficient Antimicrobial Agent against Pseudomonas Aeruginosa
| Autor: | Farooq Aziz, Mubashar Rehman, Muhammad Rafique, Muhammad Rashid, Muhammad Imran |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
biology
Pseudomonas aeruginosa Chemistry Organic Chemistry Metal Nanoparticles Nanoparticle Microbial Sensitivity Tests General Medicine Antimicrobial biology.organism_classification medicine.disease_cause Combinatorial chemistry Anti-Bacterial Agents Computer Science Applications Anti-Infective Agents Colloidal gold Drug Discovery medicine Gold Surface plasmon resonance Antibacterial activity Bacteria Antibacterial agent |
| Zdroj: | Combinatorial Chemistry & High Throughput Screening. 25:1230-1236 |
| ISSN: | 1386-2073 |
| DOI: | 10.2174/1386207324666210617163037 |
| Popis: | Aims: The study aims to develop advanced antibacterial agents as nanoparticles instead of antibiotics due to the emergence of antimicrobial resistance. Background: Pseudomonas aeruginosa is capable of causing many diseases, including severe bacterial pneumonia. There is a need for an efficient antibacterial agent to kill these pathogens. Objective: The objective of the study is to synthesize advanced antibacterial agents as nanoparticles for biomedical applications that can play a vital role in killing Gram-negative bacteria (Pseudomonas aeruginosa). Method: A novel fabricated growth of hydrophilic spiky gold nanoparticles (SGNPs) via reduction method is reported. Results: The surface plasmon resonance peak of the synthesized SGNPs was tuned under the near-infrared range. The SGNPs have anisotropic and spiky morphology with 68 nm size and -58 mV surface charge. They are pure, possessing adsorption similar to the organic material. Pseudomonas aeruginosa treated with synthesized SGNPs showed 60% bacterial death at the concentration of 100 μM. Conclusion: This work consists of the novel synthesis of SGNPs via a safe and simple reduction method. The synthesized SGNPs exhibit strong antibacterial activity against the Gram-negative bacteria Pseudomonas aeruginosa measured using a microplate assay test. The result showed that these SGNPs are ideal for biomedical applications. |
| Databáze: | OpenAIRE |
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