Sodium glucose cotransporter‐2 inhibitor was associated with an improvement in left ventricular systolic function in patients with type 2 diabetes mellitus with impaired left ventricular systolic function

Autor: Chun-Li Wang, Pao-Hsien Chu, Chien-Ying Huang, Tzyy-Jer Hsu, Yi-Wei Kao, Yi-Hsin Chan
Jazyk: angličtina
Rok vydání: 2020
Předmět:
medicine.medical_specialty
Heart failure
Systolic function
Dipeptidyl peptidase-4 inhibitor
030204 cardiovascular system & hematology
Ventricular Function
Left
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Internal medicine
Type 2 diabetes mellitus
medicine
Dipeptidyl peptidase‐4 inhibitor
Humans
Diseases of the circulatory (Cardiovascular) system
In patient
030212 general & internal medicine
Sodium-Glucose Cotransporter 2 Inhibitor
cardiovascular diseases
Sodium-Glucose Transporter 2 Inhibitors
Ejection fraction
business.industry
Type 2 Diabetes Mellitus
medicine.disease
Treatment Outcome
Diabetes Mellitus
Type 2
Echocardiography
RC666-701
Cardiology
cardiovascular system
Cardiology and Cardiovascular Medicine
business
Sodium glucose cotransporter‐2 inhibitor
medicine.drug
Cohort study
circulatory and respiratory physiology
Zdroj: ESC Heart Failure, Vol 7, Iss 5, Pp 2784-2796 (2020)
ISSN: 2055-5822
Popis: Aims Recent studies indicated that sodium glucose cotransporter‐2 inhibitors (SGLT2i) reduced heart failure hospitalization in patients with type 2 diabetes mellitus (T2DM). However, whether SGTL2i can improve left ventricular (LV) systolic and diastolic function remained unclear. This study aimed to compare the change in echocardiographic parameters in T2DM patients receiving SGLT2i with a different baseline LV ejection fraction (LVEF). The change in echocardiographic parameters was also compared between T2DM patients treated with SGLT2i and those treated with dipeptidyl peptidase‐4 inhibitor (DPP4i). Methods and results This multicentre cohort study consecutively enrolled 665, 119, and 132 T2DM patients treated with SGLT2i with a preserved (≥50%), moderately reduced (40–50%), and reduced baseline LVEF (
Databáze: OpenAIRE
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