Synthesis, fungicidal activity, and QSAR of pyridazinonethiadiazoles
| Autor: | Gui Yu Jin, Xia Juan Zou, Zu Xing Zhang |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Quantitative structure–activity relationship
Chemical Phenomena Stereochemistry Chemistry Physical Substituent Biological activity General Chemistry Biology biology.organism_classification Chemical synthesis Fungicides Industrial Fungicide Pyridazines chemistry.chemical_compound Wheat leaf rust Structure-Activity Relationship chemistry Thiadiazoles Bioassay Puccinia recondita General Agricultural and Biological Sciences |
| Zdroj: | Journal of agricultural and food chemistry. 50(6) |
| ISSN: | 0021-8561 |
| Popis: | A series of novel 5-[1-aryl-1,4-dihydro-6-methylpyridazin-4-one-3-yl]-2-arylamino-1,3,4-thiadiazoles, related to the fungicidal activity, were synthesized and tested in vivo against wheat leaf rust, Puccinia recondita. The preliminary bioassay indicated that they exhibited fungicidal activity and the activity was influenced by the nature of the substituents. A quantitative structure−activity relationship study showed that the hydrophobicity (∑π) is a major positive parameter in affecting the activity; the electronic parameters (∑σ, ∑F) are the major negative parameters in affecting the activity. Especially, introducing an ortho substituent with an inductively electron-donating property is favorable to the activity. Keywords: Synthesis; pyridazinonethiadiazoles; fungicides; wheat leaf rust; QSAR |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|