Chronically dysregulated NOTCH1 interactome in the dentate gyrus after traumatic brain injury

Autor:	Anna Maria Bot, Niina Vuokila, Noora Puhakka, Katarzyna Lukasiuk, Konrad J. Dębski, Asla Pitkänen
Přispěvatelé:	A.I. Virtanen -instituutti
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	0301 basic medicine Male Critical Care and Emergency Medicine Traumatic Brain Injury Time Factors Microarrays lcsh:Medicine Bioinformatics Interactome Biochemistry 0302 clinical medicine Animal Cells Brain Injuries Traumatic Transcriptional regulation Medicine and Health Sciences Cluster Analysis Receptor Notch1 lcsh:Science Trauma Medicine Regulation of gene expression Neurons Multidisciplinary Messenger RNA Brain Immunohistochemistry Nucleic acids Bioassays and Physiological Analysis Anatomy Cellular Types Traumatic Injury Research Article Protein Binding Traumatic brain injury Research and Analysis Methods 03 medical and health sciences Downregulation and upregulation microRNA medicine Genetics Animals Non-coding RNA Immunohistochemistry Techniques Biology and life sciences business.industry Dentate gyrus Gene Expression Profiling Hippocampal Formation lcsh:R Computational Biology Reproducibility of Results Cell Biology medicine.disease Gene regulation Rats Gene expression profiling Histochemistry and Cytochemistry Techniques MicroRNAs Disease Models Animal 030104 developmental biology Gene Expression Regulation nervous system Cellular Neuroscience Dentate Gyrus Immunologic Techniques RNA lcsh:Q Gene expression business Carrier Proteins Transcriptome Neurotrauma 030217 neurology & neurosurgery Neuroscience
Zdroj:	PLoS ONE, Vol 12, Iss 3, p e0172521 (2017) PLoS ONE
ISSN:	1932-6203
Popis:	Traumatic brain injury (TBI) can result in several dentate gyrus-regulated disabilities. Almost nothing is known about the chronic molecular changes after TBI, and their potential as treatment targets. We hypothesized that chronic transcriptional alterations after TBI are under microRNA (miRNA) control. Expression of miRNAs and their targets in the dentate gyrus was analyzed using microarrays at 3 months after experimental TBI. Of 305 miRNAs present on the miRNA-array, 12 were downregulated (p published version peerReviewed
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f57604713f0bd3a09aea1390aab86bb http://europepmc.org/articles/PMC5342204?pdf=render Zobrazit plný text záznamu Plný text ve formátu PDF