The effects of dietary supplementation with n-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: a randomized, double blind trial
| Autor: | L. T. Jensen, Faarvang Kl, K. L. Teglbjærg, Erik Berg Schmidt, Glen Nielsen, Lervang Hh, E. Ernst, Jørn Dyerberg, B. S. Thomsen, Hansen Tm |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
medicine.medical_specialty Diet therapy Clinical Biochemistry Arthritis Placebo Biochemistry Gastroenterology law.invention Arthritis Rheumatoid Randomized controlled trial Double-Blind Method law Internal medicine Fatty Acids Omega-3 medicine Humans Unsaturated fatty acid Aged chemistry.chemical_classification biology business.industry C-reactive protein General Medicine Middle Aged medicine.disease Peptide Fragments Surgery C-Reactive Protein chemistry Rheumatoid arthritis biology.protein business Procollagen Polyunsaturated fatty acid |
| Zdroj: | European journal of clinical investigation. 22(10) |
| ISSN: | 0014-2972 |
| Popis: | Study objective: To determine the effect of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on disease variables in patients with rheumatoid arthritis. Design: Multicenter, ran- domized, placebo controlled, double blind. Setting: Three Danish hospital Departments of Rheumato- logy. Patients: Fifty-one patients with active rheuma- toid arthritis. Intervention: Random allocation to 12 weeks of treatment with either six n-3 PUFA capsules (3.6 g) or six capsules with fat composition as the average Danish diet. Main results: Significant im- provement of morning stiffness and joint tenderness. No significant effect on the four other assessed clinical parameters. No serious side effects. Conclusions: Die- tary supplementation with n-3 PUFA in patients with rheumatoid arthritis improved two out of six patient reported disease parameters. Further studies are needed to clarify the more precise role of n-3 PUFA in the treatment of rheumatoid arthritis. |
| Databáze: | OpenAIRE |
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